Following its expedited launch during the V'ger incident, the warp core of the refitted USS Enterprise required new fuel equations to balance the intermix. The essential simulation of the flow sensors was bypassed resulting in an antimatter imbalance. (Star Trek: The Motion Picture)
- "The matter and antimatter tanks on a Galaxy-class starship are nine-tenths depleted. Calculate the intermix ratio necessary to reach a starbase one hundred light years away at warp factor 8."
In the same year, after the Shuttlecraft 13 crashed on Vagra II, the USS Enterprise-D was rushed to have warp drive operational. In the start-up sequence, prior to powering up the engine core and injecting reactants, the matter-antimatter injectors were primed to a ratio of 25:1. Minimal warp speeds were recommended, however Captain Jean-Luc Picard ordered warp 8. (TNG: "Skin of Evil")
In 2367, Doctor Leah Brahms was surprised that Geordi La Forge had changed the intermix ratio from Starfleet regulations. He explained that experience told him it needed to be a little lower to be more efficient. (TNG: "Galaxy's Child")