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Impedrezene was a narcotic that impeded one's ability by slowing down the higher brain cell functions. The drug could last for hours in Humans. It attacked neuro-cognitive motor function by suppressing higher cognitive abilities. Extreme headaches were associated with use of this drug after the effects had worn off. (VOY: "Alliances", "Investigations")

It is unclear whether the spelling of the term is impedrezene or impedrezine. The former spelling was the one used in the Star Trek Encyclopedia (4th ed., vol. 1, p. 360).