The hypothalamus was a region of the brain that secreted hormones. In Humans, it was located above the pituitary gland.

In the Denobulan language, the phrase for "the hypothalamus" is "Ya-sah degata". Phlox mentioned this while testing Hoshi Sato's Denobulan while she was recovering after being injured by a Romulan mine in 2152. (ENT: "Minefield" deleted scene)

After making his warp 10 flight in 2372, The Doctor detected elevated serotonin levels in Tom Paris' hypothalamus. (VOY: "Threshold")

The Akritirian clamp stimulated acetylcholine production in the hypothalamus. (VOY: "The Chute")

The Vori propaganda techniques used to forcibly train soldiers also targeted the hypothalamus. (VOY: "Nemesis")

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