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Hyperonic radiation is a type of radiation that is lethal to most humanoids. This type of radiation also renders transporters inoperable and randomizes phaser fire (although Lt. Cmdr. Data, a Soong-type android, adapted a phaser using his own circuitry to be able to fire in such an environment).

Previous Federation research suggested that Humans could adapt to hyperonic radiation, perhaps through virotherapy. (TNG: "The Ensigns of Command")

The atmosphere of the planet Tau Cygna V had an abundance of hyperonic radiation that killed one-third of the crew of the SS Artemis after they were forced to land on the planet in 2274. The survivors adapted to the radiation and thrived to build a colony of over 15,000, though exactly how they adapted was not stated. (TNG: "The Ensigns of Command")

In 2369, Doctor Julian Bashir bombarded a sample of the aphasia virus, grown on tetracitrus gel, with hyperonic radiation at 430 millirads. (DS9: "Babel")