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Histamines were substances produced by an individual in response to an allergic reaction.

When Doctor Seth Mendoza was infected with Ferengi pyrocytes in 2366, his immune system responded with a system-wide histaminic reaction. (TNG: "The Price")

An early symptom of infection by the Tarchannen III species is an allergic histamine response. (TNG: "Identity Crisis")

In Iresine syndrome, patients exhibit electropathic residue and lowered histamine count. The absence of lowered histamine levels permit the aftereffects of Ullian telepathic memory invasion to be distinguished from Iresine syndrome. (TNG: "Violations")

The Star Trek Encyclopedia (4th ed., vol. 1, p. 338) defined histamine as, "Biochemical substance produced by the breakdown of histidine, an amino acid in humanoid tissues. Histamine is produced by the body when it comes in contact with substances to which the body is sensitized, and is a primary factor in the humanoid allergic response."

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