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Grid 649 was the Borg spatial designation for a region of space in the Delta Quadrant containing or near the Brunali homeworld.
The Brunali transport vessel carrying Icheb was assimilated by a Borg cube in Grid 649. (VOY: "Child's Play")
In 2377, the Borg Queen detected two drones in Grid 649 with the mutation that allowed them access to Unimatrix Zero. (VOY: "Unimatrix Zero")