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In 2376, after Lyndsay Ballard's return to USS Voyager, The Doctor identified the genetic pathogen that had changed her into Jhet'leya but informed her that there was no longer enough of her former genome to reverse the process. He designed an inaprovaline compound that would make her cosmetically Human, but in time the pathogen began to counteract this as well. (VOY: "Ashes to Ashes")