Nuclear fusion is a physical reaction that could be harnessed as a form of power generation; it is the very process which causes stars to shine.

Helium fusion enhancement was at the center of Doctor Timicin's studies to re-vitalize the Kaelon sun. (TNG: "Half a Life")

During the late 2360s, the Romulans began performing experiments with trilithium weapons. This technology, which could be used as a nuclear inhibitor, was capable of stopping fusion within a star. As of 2371, they were unable to stabilize it. However, El-Aurian scientist Doctor Tolian Soran was able to create such a weapon, which he used to create a quantum implosion in the Amargosa star. (Star Trek Generations)

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