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Bashir first used the term when describing why he wanted to practice medicine on the newly-established Federation space station Deep Space 9, claiming it was going to be "real frontier medicine." Explaining that he had his choice of any job in the fleet after graduating medical school, Bashir stated that he wanted to be in the wilderness where the adventure was and the heroes were made. Kira Nerys took offense at this, viewing it as condescending. (DS9: "Emissary")
Bashir's desire to practice frontier medicine was initially disappointing to his parents Richard and Amsha, who expressed that he could do his medical research on Earth just as easily. (DS9: "Doctor Bashir, I Presume")