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The frontal lobe was a part of the brain located at the very front of the brain.
In 2367, Dr. Beverly Crusher detected increased neural activity localized in Jean-Luc Picard's prefrontal and parietal lobes. This was as a result of Picard's Humanity reasserting itself after his assimilation by the Borg. (TNG: "The Best of Both Worlds, Part II")