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A Cardassian's thumbprint on a Kressari PADD was all the evidence Kira Nerys needed in 2370 to prove to the Chamber of Ministers a connection between Cardassia and The Circle. Once the thumbprint established the shocking truth behind The Circle, Minister Jaro Essa's attempted coup d'etat against the Bajoran Provisional Government immediately collapsed. (DS9: "The Siege")
Thumbprints could be used in lieu of signatures. In 2374, Luther Sloan threatened Julian Bashir with confinement in a maximum security cell for the duration of the Dominion War unless he put his thumbprint on a confession. (DS9: "Inquisition")