The Federation-Tzenkethi War was a conflict between the Federation and the Tzenkethi in the 24th century. Benjamin Sisko fought in the Federation-Tzenkethi War aboard the USS Okinawa, as Captain Leyton's executive officer. (DS9: "The Adversary", "Paradise Lost")
- Given that Sisko refers to "the last Federation-Tzenkethi War" in "The Adversary", it is possible that more than one war was fought between the two powers.
- The Federation-Tzenkethi War is to be featured in an upcoming Star Trek: The Lost Era novel.