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Fatigue is a feeling of tiredness, which when symptomatic of an illness, can be either chronic or sudden.
In 2266, Doctor McCoy asked Captain James T. Kirk to allow him to enter Lieutenant Dave Bailey's insubordination in his medical records as simple fatigue. When Kirk refused, McCoy asserted that the captain overworked him and that he would challenge his decision and claim that he warned him. (TOS: "The Corbomite Maneuver")