Epsilon Indi II was the inhabited second planet in the Epsilon Indi system. This system was located less than twenty light years from the Sol system.

In the early-to-mid 24th century, on stardate 15720.4, Lieutenant Walter Pierce was born on Epsilon Indi II. This lieutenant's personnel file appeared in a hallucination of Deanna Troi's. (TNG: "Eye of the Beholder", okudagram)

In 2364, the location of Epsilon Indi was labeled in a star chart of a stellar neighborhood with Sol at the center. This chart was filed in the USS Enterprise-D library computer. (TNG: "The Naked Now", production art)

This planet was only mentioned in writing.. It was listed on a personnel file seen on a okudagram screen.
This chart naming stars within twenty light years of Sol was drawn by Rick Sternbach for the Star Trek Spaceflight Chronology in the late 1970s. Found on page 77, this chart showed Earth commercial and exploration routes after the use of warp drive began. There were no commercial or exploration routes to this system.