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Prior to stardate 5718, the Federation took advantage of the inhospitable environment for the establishment of an asylum for the criminally insane – the Elba II asylum, The asylum was administered by a governor. In 2269, the governor was Doctor Donald Cory.
In that year, the Federation starship USS Enterprise delivered a revolutionary new medicine to this asylum. The hope with this medicine was that it would permanently eliminate mental illness. A patient at this asylum, Captain Garth of Izar, a former Starfleet Fleet Captain, was treated with this medicine. (TOS: "Whom Gods Destroy")