Dramia II was the inhabited second planet in the Dramen star system. Some time prior to 2251, the planet was colonized by the Dramens.

In 2251, Dramia II was visited by Leonard McCoy, who was the head of a massive inoculation program on the planet. While on Dramia II, McCoy saved a Dramian colonist, named Kol-Tai, from a strain of the Saurian virus. Shortly after McCoy departed, the colony was hit by an auroral plague that killed most of the planet's colonists. McCoy was blamed for their deaths.

Nineteen years later, McCoy was arrested and charged for the mass murder of Dramia II's inhabitants. He later found an antidote for the plague and was cleared of all charges. (TAS: "Albatross")

According to the script on the surface, "the planet is a study in desolation; it is the outer space equivalent of "Devil's Island"–if Devil's Island were a leper colony." It was also described as having a "moon-like landscape."
According to Star Trek: Star Charts ("United Federation of Planets I"), in 2378, Dramia II was a Federation member.