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Drake can refer to:
- Drake, a 22nd century Human archaeologist
- Drake, a shuttlecraft of the USS Voyager
- USS Drake (2364), the first of two different Federation starships
- USS Drake (2373), the second of two Federation starships
- Drake equation, a way to estimate the number of extraterrestrial alien species
- Dawn Drake, an actress in Star Trek: Enterprise
- Jacqueline Drake, and actress in TNG "Angel One"
- Larry Drake, an actor in VOY "Critical Care"
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