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Dolamide was a versatile chemical-based energy source used in such technology as power generators, reactors, transporters, and short-range transports. In extremely pure form, dolamide could also be used to manufacture weapons.

The Valerians supplied the Cardassians with weapons-grade dolamide in the 2360s. On the planet Ultima Thule was a dolamide purification plant. (DS9: "Dramatis Personae")

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