Devil's Island was an island off the coast of northeastern South America, in the North Atlantic Ocean. The island was the location of a penal settlement in the 19th and 20th centuries.

In 2266, Dr. Tristan Adams welcomed Dr. Helen Noel to the Tantalus colony by saying, "Welcome to 'Devil's Island,' doctor." (TOS: "Dagger of the Mind")

The final draft script of "Dagger of the Mind" established this line was a standard joke at the Tantalus colony.

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