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Common symptoms of dehydration included increased thirst and tiredness. (VOY: "Ex Post Facto") In some humanoids (such as Arkonians), dehydration caused acute cellular breakdown which increased the risk of transporter accidents. (ENT: "Dawn")
When in an environment conducive to dehydration (such as a desert), breathing through one's nose helped to prevent the body from losing too much water. Captain Jean-Luc Picard recommended this to Wesley Crusher when the pair crash-landed on the moon Lambda Paz in 2367. (TNG: "Final Mission")
Neodextramine solution was a medicine that could be used to treat dehydration. After Harry Kim was forced to return to the USS Voyager from Banea in 2371, he suffered from dehydration in his shuttle. Upon returning, he was given a neodextramine solution. (VOY: "Ex Post Facto")