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Memory Alpha
Francoise de Picard and Madame de La Barre

Madame de La Barre (Left) and Francoise de Picard (right)

Madame de La Barre was a French woman that was married to Francoise de Picard in ancient 16th century France.

She and Francoise de Picard were the founders of the Picard family line, and drawings of them are on the first page of the Picard family album. She was a distant ancestor of Starfleet Captain Jean-Luc Picard. (Star Trek: Generations)

This and the family tree in the album imply that they are the farthest back recorded Picard or La Barre known.
This information comes from the Picard family album and was not seen onscreen.
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