D'Nesh was a female Orion slave girl who, along with her sisters, were given to Captain Jonathan Archer by Harrad-Sar as a present to celebrate a trade agreement with the Orion Syndicate. D'Nesh and her sisters exposed the ship to a very potent pheromone that put all the men on the ship in a state of aggression that causes delusions. D'Nesh went to engineering, and received a tour from Kelby. Later, she seduced Kelby and convinced him to sabotage the Enterprise NX-01's engines and attack Trip. Later, she was able to persuade Reed to help arrest T'Pol.