The Creators was what the Fabrini who lived on the asteroid spaceship Yonada called their ancestors. Faced with their sun about to go nova, the creators built the spaceship and left the Book of the People to their descendants, which was to be opened when the ship reached its destination.
By 2268, the creators were revered as gods by their Fabrini. They were taught to worship and not offend their creators. Any individuals who joined the community, like Leonard McCoy, were required to likewise follow suit. (TOS: "For the World is Hollow and I Have Touched the Sky")