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Cor Caroli V was the location of an outbreak of Phyrox plague in 2366. The USS Enterprise-D successfully eliminated the plague, and Starfleet Command classified the incident as secret. When Captain, Jean-Luc Picard was kidnapped and held along with three other individuals of other species, one of which was actually one of the kidnappers posing as a Bolian Starfleet cadet named Mitena Haro, her knowledge of the Enterprise's visit to this planet led him to realize she might be an imposter. (TNG: "Allegiance")