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In 2375, Benjamin Sisko, preoccupied by the latter stages of the Dominion War, forgot to renew his injection despite repeated reminders from his CMO Julian Bashir. As a result, his wife, Kasidy Yates, became pregnant with their child, the couple's first. (DS9: "The Dogs of War")
Background information Edit
In The Making of Star Trek, it is stated that the birth control practiced on board the USS Enterprise was never discussed in any episode of The Original Series because the censors would not have allowed it. But if it were to have been discussed, they would have explained contraception to be based on monthly injections mandatory for unmarried women and voluntary for married women. If a member of the crew became pregnant, she would have a choice between medical discharge or rotation to a shore base for the duration of the pregnancy. (pages 206, 207)