Istanbul was an ancient Earth city located in Eurasia. In early history, it was known as Constantinople.

In the 13th century, one Crusade resulted in the Sack of Constantinople. (TOS: "The Squire of Gothos", DS9: "Q-Less", VOY: "The Killing Game")

In summer 1334, Constantinople was affected by the Bubonic plague while Flint was in the city. (TOS: "Requiem for Methuselah")

During the 19th and 20th centuries, the city was the destination of the Orient Express. (TNG: "Emergence")

In the Julian Bashir, Secret Agent holoprogram set in the 1960s, Istanbul sent several messages to an island in the South Pacific, that were intercepted by the Americans. (DS9: "Change of Heart")

The USS Constantinople was named after the historic name for this city, and the Star Trek Encyclopedia (4th ed., p. 158) classified it as an Istanbul-class starship.

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