Columbus Avenue was a street in late 20th century San Francisco. Winchell's Donut House was located at the corner of Columbus and Kearny Street, as well as a no right turn sign. Further down this street, to the northwest, there was an antiques store. Past this point, the street intersected with Greenwich Street and Mason Street. To the southeast, this street ended at the Transamerica Pyramid.

In 1986, a bus of 30-Stockton and a cable car of Powell & Mason, a San Francisco Municipal Railway route and line, respectively, were seen traveling this street when Nyota Uhura and Pavel Chekov were asking passersby for directions to the naval base in Alameda. (Star Trek IV: The Voyage Home)

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