(covers information from several alternate timelines)
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A colorful metaphor, or profanity, is a use of slang language or physical expression intended to emphasize derision, curses, or other emotional outbursts. Although such usages were uncommon in the 23rd and 24th centuries, they were an essential part of 20th century conversation, seen in the novels of "giants" such as Jacqueline Susann and Harold Robbins.
In 2063, Lily Sloane used the expletive "bullshit" twice in response to Captain Jean-Luc Picard of the USS Enterprise-E when his crew traveled to her time to stop the Borg's attempt to prevent first contact. She first used it when Picard told her that he was here to help while she was firing at him and Data, she later used it when he denied that he had a desire for revenge against the Borg. (Star Trek: First Contact)
In 2152, when the Vulcan ambassador Soval maneuvered to end the mission of the Enterprise NX-01, Commander Charles Tucker III stated of him to Doctor Phlox, "They'll probably give the son of a bitch some gaudy medal and then cart him off to wherever they send bitter old Vulcans to retire." (ENT: "Shockwave")
A bit later that same year, when Silik desperately tried to contact his benefactor at the Helix, Jonathan Archer emerged and attacked Silik. He answered "I said you're an ugly bastard" to Silik, who had just asked his benefactor to repeat what he said before Archer arrived. (ENT: "Shockwave, Part II")
In 2153, Charles Tucker III called Kessick a "stupid son of a bitch". Later, Captain Archer cursed, "The son of a bitch lied to us!", after discovering the destroyed Xindi homeworld Kessick sent Enterprise to. (ENT: "The Xindi")
Later that same year, Captain Archer described Commander Shran as a "son of a bitch" after he and his vessel, the Kumari, refused to surrender the second prototype of the Xindi weapon. (ENT: "Proving Ground")
In an alternate reality (circa 2245), a young James T. Kirk played the song "Sabotage" as he drove his stepfather's 1965 Chevy Corvette on a joyride through the Iowa countryside, which included "fuckin'" in its lyrics.
In 2259, James T. Kirk used the colorful metaphor "Damn it" when he found out that the warp drive on the USS Enterprise had a coolant leak and that it would take 20 minutes to get to Qo'noS in the K'normian trading ship they had confiscated. Kirk also use "Shit" when he lost track of Khan Noonien Singh for a brief second on the USS Vengeance. (Star Trek Into Darkness)
In 2285, Doctor Leonard McCoy referred to Spock as "that green-blooded son of a bitch", while suffering from the transfusion of the Vulcan's katra into his own mind. (Star Trek III: The Search for Spock)
When the crew of the USS Enterprise time traveled to 1986, James T. Kirk began using "colorful metaphors" in an effort to blend in though he felt that Spock shouldn't attempt them, as he didn't "have the knack." (Star Trek IV: The Voyage Home)
Spock mastered them fairly quickly, as he exclaimed "Damn you, sir!" to General Korrd to impel him to use his authority to command Klaa to stand down. Kirk had earlier shouted a series of curses on Spock for allowing Sybok to take over the Enterprise, "Dammit, Spock! Goddammit!" adding "I oughta knock you on your goddamned ass!" (Star Trek V: The Final Frontier)
In 2293, Montgomery Scott referred to the new Klingon Chancellor, Azetbur, as "That Klingon bitch killed her father". Soon thereafter, Spock suggested that "Go to hell" might be an appropriate Human response to the order for the USS Enterprise-A to be decommissioned. (Star Trek VI: The Undiscovered Country)
The following year, Picard used the same expletive when Geordi La Forge realized that he had inadvertently invested James Moriarty with consciousness by misstating a command to the computer. (TNG: "Elementary, Dear Data")
In 2366, William T. Riker commented that Alidar Jarok's knowledge of Klingon curses was impressive, after Jarok had referred to Worf as both a PetaQ, and a tohzah, adding that "only a Veruul would use such language in public." (TNG: "The Defector")
After Montgomery Scott was released from the USS Jenolan's transporter in 2369, he initially argued with the Enterprise-D's computer while attempting to view the bridge of the original Enterprise in the holodeck, finally (through gritted teeth and frustration brought on by intoxication) specifying the ship's registry number as "NCC-1701 – no bloody USS EnterpriseA, USS EnterpriseB, USS EnterpriseC, or USS EnterpriseD." (TNG: "Relics")
When the USS Enterprise-D was about to crash into Veridian III, Data expressed the shock and horror he felt (thanks to his newly installed emotion chip) with a suitably colorful metaphor, saying "Oh, shit." (Star Trek Generations)
The Species 8472 recreation of Boothby, stationed on Terrasphere 8, referred to the concepts making up the United Federation of Planets: "tolerance for all species, the Prime Directive" as "targ manure," during talks with Kathryn Janeway and the senior staff of USS Voyager. In response to those statements, Tuvok corrected Boothby and stated "your metaphor is colorful, but inaccurate." (VOY: "In the Flesh")
In 2258, James T. Kirk, banished to Delta Vega for attempted "mutiny" on the orders of Spock, used the "accurate" version of this metaphor, "bullshit", when the old Vulcan who saved him from becoming a native beast's dinner – who not only recognized him on sight but professed to be his lifelong friend – identified himself as Spock. (Star Trek)
Miles O'Brien used mild Irish expletives, usually the word "bloody." On one particular occasion, when Molly O'Brien fell into the past through a time portal on the planet Golana, he used the stronger expletive "bollocks" when some of the equipment he used in an attempt to retrieve her malfunctioned. (DS9: "Emissary", "Q-Less", "Empok Nor", "Time's Orphan")