Clare was married to Donald Raymond with two sons, Tommy and Edward. When she died of an embolism at 35 years old, her husband had her body frozen and stored in a cryonics satellite. The satellite drifted in space for more than three centuries until the USS Enterprise-D found it in 2364 near the Kazis binary system.
Not knowing what to do with the frozen bodies he discovered, Data brought her back to the Enterprise-D, where Dr. Crusher revived and cured her. Clare returned to Earth aboard the USS Charleston. She had decided to look up her descendants, in particular Thomas Raymond, who was living in the Indianapolis area. (TNG: "The Neutral Zone")