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A comparison of Icheb's chromosomes to those of a typical Brunali male

A chromosome is a long, continuous strand of DNA that contained genes and regulatory elements. It is a macromolecular unit of genetic information. Humans have 23 chromosome pairs.

Chromosomes can be negatively impacted by:

This was not the full list of environmental factors which could have impacted the chromosomes in the Star Trek universe. There were other factors, some unreadable, some puzzling, and some intended as in-jokes, such as Bad Personal Hygiene or Red Dye Number Two.

In 2369, Julian Bashir and Jadzia Dax ran a chromosome scan of a clone of Ibudan. (DS9: "A Man Alone")

In 2372, The Doctor used undamaged chromosomes from Denara Pel's cerebellum to recreate her original DNA code. (VOY: "Lifesigns")

When the Silver Blood USS Voyager and its crew began to deteriorate from subspace radiation in 2375, The Doctor found that their chromosomes were breaking down on a molecular level. (VOY: "Course: Oblivion")

The Brunali made microgenetic alterations in the 3rd, 13th, and 17th chromosomes of certain children so that they would produce a spaceborne virus, turning them into weapons against the Borg. (VOY: "Child's Play")

During an away mission in the Delta Flyer in 2376, Mortimer Harren asserted that genetics, not environment, were the determining factor in personality. In response, Captain Janeway jokingly asked, "How's your 13th chromosome? Missing a couple of base pairs in gene 178?" (VOY: "Good Shepherd")

This was likely a reference to the chromosome considered responsible for development.

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