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Christopher Columbus was a famed Genoese navigator and explorer who sailed for Spain during the 15th and 16th centuries. According to Sybok, he proved his world was round rather then flat. (Star Trek VI: The Undiscovered Country)
Nora, a friend of Travis Mayweather's who resided on the ECS Horizon, compared Mayweather to Columbus and Magellan after he explained to her that the exploration feats he participated in aboard the Enterprise, which included having traveled 150 light years and visiting twenty-two inhabited worlds in an eighteen-month period. (ENT: "Horizon")
Columbus' legacy was honored well into the 23rd century as the name of a Federation shuttlecraft assigned aboard the USS Enterprise and USS Enterprise-A. (TAS: "The Slaver Weapon"; Star Trek V: The Final Frontier)