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The chameleon was a small lizard native to Earth.

While discussing the salt vampire's natural ability to take other forms, Robert Crater and Leonard McCoy discussed the similarity the creature bore to the chameleon, which possessed a natural ability to use protective coloring to survive in nature. (TOS: "The Man Trap")

Doctor Beverly Crusher compared the Tarchannen III species to a chameleon, as the skin of the lifeform had similar mimetic qualities. (TNG: "Identity Crisis")

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