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(covers information from several alternate timelines)
The planet exploded for reasons unknown in 2267, approximately six months after Khan Noonien Singh and his followers were exiled on Ceti Alpha V. The shock of the explosion shifted the orbit of Ceti Alpha V, destroying that planet's ecosystem. In 2285, the USS Reliant arrived in the Ceti Alpha system to find a suitable planet for the Genesis Device. Pavel Chekov and Captain Clark Terrell beamed down to Ceti Alpha V, mistakenly thinking it was Ceti Alpha VI. Just before they were captured by Khan and his Augments, Chekov realized that they had made a grave error. (Star Trek II: The Wrath of Khan)
In an alternate timeline, Human refugees fled to the Ceti Alpha system, following the Xindi's successful destruction of Earth in February 2154, during the relentless pursuit of the Xindi to eradicate all Human colonies. (ENT: "Twilight")