Prior to stardate 41309, the natives of Cerberus II had developed a medical process, widely thought to be only a myth, that rejuvenated aged bodies. The process was quite dangerous and painful and was not usually administered to aliens. However, in 2364, Starfleet Admiral Mark Jameson, who years before had negotiated a treaty on the planet, was able to obtain two courses of the treatment. He intended to administer the first to himself to treat his Iverson's Disease and as a test of the treatment on Humans, and, if he succeeded, the second to his wife.
The process consisted of herb and drug combinations that were self-administered over a period of two years, and the reaction to the treatment depended on the individual being treated, specifically their DNA.
In an attempt to rapidly strengthen himself, Admiral Jameson consumed both the remainder of his doses, and all of his wife's, a move that ultimately caused his health to deteriorate even more rapidly. (TNG: "Too Short a Season")