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A cardiostimulator was among the medical equipment, E'Lis received from Doctor Phlox in 2152 to treat the injuries in their mining colony. Phlox noted that he was unaware that processing deuterium was such a dangerous business. (ENT: "Marauders")
In 2268, Doctor Leonard McCoy used a portable version of the device aboard the USS Enterprise during an operation on Ambassador Sarek, after the power to sickbay had failed and the operating table's own cardiostimulator had ceased functioning. (TOS: "Journey to Babel")
In 2378, Tom Paris used a cardio-stimulator to cajole the heart of Brin's son to life. Although the initial charge of 3 millijoules was unsuccessful, the second charge set at 5 millijoules was successful. (VOY: "Friendship One")