A cardinal was a high position in the Roman Catholic branch of Christianity.

Within a holoprogram set in 16th century Florence, Leonardo da Vinci painted two portraits of a certain cardinal's nephew depicting him like a heroic Achilles or Hercules, for which Da Vinci received only the cardinal's "eternal gratitude". (VOY: "Scorpion")

The character of Richelieu was a cardinal. Traditionally, cardinals are addressed as eminence.

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