The Cardassian operational guidelines were the written instructions for operating a Cardassian space station.

In 2369, Chief Miles O'Brien ordered an increase in the deuterium flow to the reaction chamber two by five percent. The Deep Space 9 computer stated that this procedure was not recommended and suggested he consult paragraph 254A. This paragraph was then displayed on a screen. The chief refused to read the tech manual and did the task without the computer. (DS9: "The Forsaken")

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