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Cancri IV was the fourth planet in the Cancri system, inhabited by the Cancri.

In 2256, the elders of Cancri IV hosted a secret meeting between Vulcan and two independent Klingon Great Houses to discuss the possibility of an alliance. They organized this meeting on neutral ground.

However, the meeting was a ruse created by Kol in order to capture Ambassador Sarek, whom he had invited to the meeting. Due to a injury, though, Sarek did not attend the meeting and Admiral Katrina Cornwell went in his place. Though Kol had wanted to capture a Vulcan, he settled for taking Cornwell. In the process of doing so, the Cancri hosts of the meeting and Cornwell's security escort were all killed. (DIS: "Lethe")

According to the revised Stellar Cartography: The Starfleet Reference Library ("History of the United Federation of Planets"), the Cancri system was located in the Beta Quadrant.