Bryma Colony was a Cardassian colony on the planet Bryma. The colony had a limited sensor range.

In 2370, this colony was, according to Dukat's sources, the location of a weapons depot. This depot was targeted for destruction by the Maquis. A Maquis cell led by Calvin Hudson attempted to launch an attack against the colony with appropriated Federation attack fighters. They were intercepted in the colony's star system by runabouts from Deep Space 9, and the attack was turned back. (DS9: "The Maquis, Part II")

This colony was only mentioned in dialogue.