The Brechtian Cluster was a region of space containing two inhabited planets.

In 2368, all life on those planets were threatened by the Crystalline Entity. The USS Enterprise-D was able to intercept the Entity before it reached the Brechtian Cluster. (TNG: "Silicon Avatar")

The Star Trek Encyclopedia (4th ed., vol. 1, p. 102) identified the Brechtian Cluster as a star system.
"Brechtian" is a word refering to the literary style of Bertolt Brecht

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