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The brain probe was a device in the The Adventures of Captain Proton holoprogram. It was used as a method of torture in order to gain information.
The Twin Mistresses of Evil, Malicia and Demonica, attempted to use one on Buster Kincaid before being stopped by Captain Proton. (VOY: "Thirty Days")
The Cradle of Persuasion was equipped with a brain probe and a pain modulator. (VOY: "Bride of Chaotica!")