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In 2373, a Pah-wraith possessing Keiko O'Brien's body told Miles O'Brien that even if he managed to stun her, it would only need a split second to cause a fatal brain hemorrhage. (DS9: "The Assignment")
The sentient ship Alice was capable of causing a cerebral hemorrhage in individuals who had linked to her neurogenic interface. She used this method to attack Abaddon in 2376, and did the same to Tom Paris. (VOY: "Alice")