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Cancer was a disease in which cells divided uncontrollably. It was one of the deadliest diseases on Earth until scientist Pyong Ko discovered the genetic sequence for inhibiting the growth of cancer cells. (VOY: "Fury")
Entities seen as evil or undermining were also referred to as cancers. In a 2268 speech, the Ekosian Melakon referred to the Zeons as a cancer which was eating away at their state. (TOS: "Patterns of Force")