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Blood vessels were part of the circulatory system and functioned to transport blood throughout humanoid bodies. Vulcan mind melds could cause pressure changes in a subject's nerves and blood vessels, something which Spock cautioned Simon Van Gelder about before beginning a meld with him in 2266. (TOS: "Dagger of the Mind")
Bajoran pregnancies developed blood vessels connecting the mother and child very quickly, as the gestation period was less than five months. For this reason, Dr. Julian Bashir recommended against removing Kirayoshi O'Brien's transplanted fetus from Kira Nerys's womb, as there was a risk of hemorrhage for her and respiratory trauma for the child. (DS9: "Body Parts")
In 2373, a Pah-wraith possessing Keiko O'Brien threatened Miles O'Brien that by destroying even a tiny blood vessel in her brain it would destroy all of Keiko's memories and emotions if he didn't cooperate. (DS9: "The Assignment")
In 2374, The Doctor diagnosed a Romulan officer with third-degree burns, a hairline fracture of the jaw, and a ruptured blood vessel in his brain which required surgical intervention. (VOY: "Message in a Bottle")