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A blight was a disease affecting plants that caused sudden death. The term could also be used to refer to any sudden disease.

In 2373, Keiko O'Brien worked to try and get a blight under control on Bajor. (DS9: "Business as Usual")

The con artists Dala and Mobar, posing as clerics, told Neelix and Tom Paris a story about the crops grown in hydroponic pods for the orphans on Narva being infected by a blight. (VOY: "Live Fast and Prosper")

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