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In 2369, Vedek Winn Adami accused Keiko O'Brien's secular teachings of the Bajoran wormhole and the Prophets as being blasphemous. Later, a member of a crowd that followed Winn said that Benjamin Sisko would "pay in eternity for his blasphemy". (DS9: "In the Hands of the Prophets")
That same year, Q told a seemingly-deceased Jean-Luc Picard that Q was God, to which Picard scoffed. Q referred to this as "blasphemy", remarking that Picard was fortunate he did not cast him away or smite him or "something". (TNG: "Tapestry")