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In 2378, Seven of Nine's biradial clamp was out of alignment by 0.3 microns causing shoulder pain, a problem easy to fix for The Doctor. Seven wanted to remove the clamp, but this would have prevented her from using the arm. (VOY: "Human Error")
Later that year, Two of Three, one of the characters in the Tom Paris-rewritten version of Photons Be Free, suffered from the same misalignment, which The Doctor "cured" by giving her a Klingon aphrodisiac. (VOY: "Author, Author")