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Asphyxia or asphyxiation was a condition of severely deficient supply of oxygen to the body that arose from abnormal breathing.

In 2267, James T. Kirk told Spock that without a functioning PXK pergium reactor, they had a choice of "death by asphyxiation or death by radiation poisoning". (TOS: "The Devil in the Dark")

Also that year, Khan Noonien Singh threatened the crew of the USS Enterprise with asphyxiation until they were willing to negotiate with him. (TOS: "Space Seed")

When Tom Paris operated a 1936 Ford truck in a USS Voyager cargo bay in 2371, the resulting high levels of smoke caused Tuvok to suggest increasing the ventilation before everyone was asphyxiated. (VOY: "The 37's")

In an alternate timeline in 2374, The Doctor expressed surprise that Harry Kim did not asphyxiate after twelve minutes' exposure to nebula gas. (VOY: "Year of Hell, Part II")

When the air was sucked out of Voyager's bridge by a Class J nebula lifeform in 2376, Captain Janeway was almost asphyxiated as she attempted to reroute emergency power to environmental controls. (VOY: "The Haunting of Deck Twelve")

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