Captain Spock once implied that he was a descendant of Doyle's – "An ancestor of mine maintained, that if you eliminate the impossible, whatever remains, however improbable, must be the truth." (Star Trek VI: The Undiscovered Country)
- Star Trek VI: The Undiscovered Country director and screenplay writer Nicholas Meyer had previously written the screenplay for The Seven-Per-Cent Solution, based on his novel. The film and book feature Sherlock Holmes, Arthur Conan Doyle's creation. This may be the reason that Spock implies that he is a descendant of Doyle's through his mother Amanda Grayson.
- Although Professor Moriarty described Conan Doyle as an Englishman in "Ship in a Bottle", he was in fact Scottish.
- A. Conan Doyle received credit as the Sherlock Holmes characters creator in the end credits of the TNG Season 6 episode "Ship in a Bottle". It was also mentioned that this use was arranged with Dame Jean Conan Doyle.