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Appetite was an individual's desire for food.
In 2254, Christopher Pike asked the The Keeper why, instead of threatening him with the experience of hell to force him to eat, the Talosian couldn't simply put irresistible hunger in his mind. (TOS: "The Cage", "The Menagerie, Part II")
In 2266, when asked by Captain Kirk why Spock hadn't shown signs of infection from the an unknown illness, Doctor McCoy suggested that maybe "the little bugs or whatever they are have no appetite for green blood" (TOS: "Miri")